Strikingly, we found that the urothelium derived from sensitized USCs recapitulated many of the morphological differences observed previously in vivo 6 even after many passages, including smaller surface cells and decreased expression of the terminal differentiation markers Upk3a and K20 when compared with differentiated urothelium derived from nave and resolved USCs (Fig
doi:10.1186/s12937-023-00908-y Zarshenas N, Tapsell LC, Batterham M, Neale EP, Talbot ML
Because sulforaphane upregulates Phase II detoxification enzymes that have a half-life of several days, daily dosing is usually sufficient to maintain a robust antioxidant shield
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Indications: FDA : Topical anesthesia of the upper respiratory tract (due to its combined vasoconstrictor & local anesthetic properties) Off Label : Use in Emergency Department as one ingredient in a topical anesthetic solution called TAC (containing: Tetracaine, Adrenaline & Cocaine) that is applied to a wound prior to cleaning & suturing Contraindications: Hypersensitivity to ester anesthetics Side Effects: Acute signs of systemic toxicity include can include multiple signs of both CV & CNS stimulation: tachycardia hypertension hyperthermia mydriasis seizures cardiac arrhythmias (multiple contributing variables: Na & K channel block, possible coronary vasoconstriction) Acute effects associated with cocaine abuse
